Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner

Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present stud...

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Detalles Bibliográficos
Autores principales: Dai, Wen-Ling, Liu, Xin-Tong, Bao, Yi-Ni, Yan, Bing, Jiang, Nan, Yu, Bo-Yang, Liu, Ji-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235923/
https://www.ncbi.nlm.nih.gov/pubmed/30429454
http://dx.doi.org/10.1038/s12276-018-0175-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235923/
https://www.ncbi.nlm.nih.gov/pubmed/30429454
http://dx.doi.org/10.1038/s12276-018-0175-1

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