Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD(+)

Cell models of mitochondrial complex I (CI) deficiency display activation of glycolysis to compensate for the loss in mitochondrial ATP production. This adaptation can mask other relevant deficiency-induced aberrations in cell physiology. Here we investigated the viability, mitochondrial morphofunct...

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Detalles Bibliográficos
Autores principales: Iannetti, Eligio F., Smeitink, Jan A. M., Willems, Peter H. G. M., Beyrath, Julien, Koopman, Werner J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235972/
https://www.ncbi.nlm.nih.gov/pubmed/30429455
http://dx.doi.org/10.1038/s41419-018-1179-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235972/
https://www.ncbi.nlm.nih.gov/pubmed/30429455
http://dx.doi.org/10.1038/s41419-018-1179-4

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