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Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD(+)
Cell models of mitochondrial complex I (CI) deficiency display activation of glycolysis to compensate for the loss in mitochondrial ATP production. This adaptation can mask other relevant deficiency-induced aberrations in cell physiology. Here we investigated the viability, mitochondrial morphofunct...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235972/ https://www.ncbi.nlm.nih.gov/pubmed/30429455 http://dx.doi.org/10.1038/s41419-018-1179-4 |