Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress

Substance use and addiction are disproportionately experienced by individuals with a history of exposure to early life stress (ELS), such as maltreatment, domestic violence and parent psychopathology. Unfortunately, extant interventions have mixed effectiveness at improving outcome trajectories for...

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Autores principales: Roos, Leslie E., Horn, Sarah, Berkman, Elliot T., Pears, Katherine, Fisher, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236514/
https://www.ncbi.nlm.nih.gov/pubmed/30450387
http://dx.doi.org/10.1016/j.ynstr.2018.10.004
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author Roos, Leslie E.
Horn, Sarah
Berkman, Elliot T.
Pears, Katherine
Fisher, Philip A.
author_facet Roos, Leslie E.
Horn, Sarah
Berkman, Elliot T.
Pears, Katherine
Fisher, Philip A.
author_sort Roos, Leslie E.
collection PubMed
description Substance use and addiction are disproportionately experienced by individuals with a history of exposure to early life stress (ELS), such as maltreatment, domestic violence and parent psychopathology. Unfortunately, extant interventions have mixed effectiveness at improving outcome trajectories for ELS-exposed children, who are often underserved by evidenced-based programs. Here, we employ a translational neuroscience framework to delineate how neuroscience can deepen our understanding of ELS-linked alterations in children's function to inform the development of more targeted, effective early intervention and addiction prevention programs. Candidate neural pathways altered by ELS and linked to addiction are described across sensory, affective, motivational, and executive function domains. Next, we provide an example of the application of translational neuroscience principles in a family of early interventions (i.e. Multidimensional Treatment Foster Care – Preschool, Kids in Transition to School) focused on improving self-regulation in ELS-exposed children. Future directions and areas of unmet need in intervention research detail the significant potential of translational neuroscience to advance interventionists' ability to support positive adjustment in ELS-exposed children and prevent harmful addiction outcomes.
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spelling pubmed-62365142018-11-16 Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress Roos, Leslie E. Horn, Sarah Berkman, Elliot T. Pears, Katherine Fisher, Philip A. Neurobiol Stress Articles from the Special Issue on Stress and substance abuse; Edited by Roger Sorensen, Da-Yu Wu, Karen Sirocco, Cora lee Wetherington and Rita Valentino Substance use and addiction are disproportionately experienced by individuals with a history of exposure to early life stress (ELS), such as maltreatment, domestic violence and parent psychopathology. Unfortunately, extant interventions have mixed effectiveness at improving outcome trajectories for ELS-exposed children, who are often underserved by evidenced-based programs. Here, we employ a translational neuroscience framework to delineate how neuroscience can deepen our understanding of ELS-linked alterations in children's function to inform the development of more targeted, effective early intervention and addiction prevention programs. Candidate neural pathways altered by ELS and linked to addiction are described across sensory, affective, motivational, and executive function domains. Next, we provide an example of the application of translational neuroscience principles in a family of early interventions (i.e. Multidimensional Treatment Foster Care – Preschool, Kids in Transition to School) focused on improving self-regulation in ELS-exposed children. Future directions and areas of unmet need in intervention research detail the significant potential of translational neuroscience to advance interventionists' ability to support positive adjustment in ELS-exposed children and prevent harmful addiction outcomes. Elsevier 2018-10-26 /pmc/articles/PMC6236514/ /pubmed/30450387 http://dx.doi.org/10.1016/j.ynstr.2018.10.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the Special Issue on Stress and substance abuse; Edited by Roger Sorensen, Da-Yu Wu, Karen Sirocco, Cora lee Wetherington and Rita Valentino
Roos, Leslie E.
Horn, Sarah
Berkman, Elliot T.
Pears, Katherine
Fisher, Philip A.
Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title_full Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title_fullStr Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title_full_unstemmed Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title_short Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
title_sort leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress
topic Articles from the Special Issue on Stress and substance abuse; Edited by Roger Sorensen, Da-Yu Wu, Karen Sirocco, Cora lee Wetherington and Rita Valentino
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236514/
https://www.ncbi.nlm.nih.gov/pubmed/30450387
http://dx.doi.org/10.1016/j.ynstr.2018.10.004
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