Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilat...

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Detalles Bibliográficos
Autores principales: Murtaza, Ghulam, Paddenberg, Renate, Pfeil, Uwe, Goldenberg, Anna, Mermer, Petra, Kummer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236867/
https://www.ncbi.nlm.nih.gov/pubmed/30284509
http://dx.doi.org/10.1177/2045894018808240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236867/
https://www.ncbi.nlm.nih.gov/pubmed/30284509
http://dx.doi.org/10.1177/2045894018808240

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