hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation

BACKGROUND: Somatic copy number alternation (SCNA) is a common feature of the cancer genome and is associated with cancer etiology and prognosis. The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and the tu...

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Detalles Bibliográficos
Autores principales: Choo-Wosoba, Hyoyoung, Albert, Paul S., Zhu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236906/
https://www.ncbi.nlm.nih.gov/pubmed/30428830
http://dx.doi.org/10.1186/s12859-018-2412-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236906/
https://www.ncbi.nlm.nih.gov/pubmed/30428830
http://dx.doi.org/10.1186/s12859-018-2412-y

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