Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP...

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Detalles Bibliográficos
Autores principales: Gao, Cheng-Zhi, Dong, Wei, Cui, Zhi-Wen, Yuan, Qiong, Hu, Xia-Min, Wu, Qing-Ming, Han, Xianlin, Xu, Yao, Min, Zhen-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237161/
https://www.ncbi.nlm.nih.gov/pubmed/30427217
http://dx.doi.org/10.1080/14756366.2018.1530224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237161/
https://www.ncbi.nlm.nih.gov/pubmed/30427217
http://dx.doi.org/10.1080/14756366.2018.1530224

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