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Synthetic protein alignments by CCMgen quantify noise in residue-residue contact prediction
Compensatory mutations between protein residues in physical contact can manifest themselves as statistical couplings between the corresponding columns in a multiple sequence alignment (MSA) of the protein family. Conversely, large coupling coefficients predict residue contacts. Methods for de-novo p...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237422/ https://www.ncbi.nlm.nih.gov/pubmed/30395601 http://dx.doi.org/10.1371/journal.pcbi.1006526 |