HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Detalles Bibliográficos
Autores principales: LaBranche, Celia C., McGuire, Andrew T., Gray, Matthew D., Behrens, Shay, Zhou, Tongqing, Sattentau, Quentin J., Peacock, James, Eaton, Amanda, Greene, Kelli, Gao, Hongmei, Tang, Haili, Perez, Lautaro G., Saunders, Kevin O., Mascola, John R., Haynes, Barton F., Stamatatos, Leonidas, Montefiori, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237427/
https://www.ncbi.nlm.nih.gov/pubmed/30395637
http://dx.doi.org/10.1371/journal.ppat.1007431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237427/
https://www.ncbi.nlm.nih.gov/pubmed/30395637
http://dx.doi.org/10.1371/journal.ppat.1007431

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