Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil

Relapse‐specific mutations in phosphoribosyl pyrophosphate synthetase 1 (PRPS1), a rate‐limiting purine biosynthesis enzyme, confer significant drug resistances to combination chemotherapy in acute lymphoblastic leukemia (ALL). It is of particular interest to identify drugs to overcome these resista...

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Detalles Bibliográficos
Autores principales: Wang, Dan, Chen, Yao, Fang, Houshun, Zheng, Liang, Li, Ying, Yang, Fan, Xu, Yan, Du, Lijuan, Zhou, Bin‐Bing S., Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237573/
https://www.ncbi.nlm.nih.gov/pubmed/30255549
http://dx.doi.org/10.1111/jcmm.13907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237573/
https://www.ncbi.nlm.nih.gov/pubmed/30255549
http://dx.doi.org/10.1111/jcmm.13907

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