Inhibition of XPO1 enhances cell death induced by ABT‐199 in acute myeloid leukaemia via Mcl‐1

The antiapoptotic Bcl‐2 family proteins play critical roles in resistance to chemotherapy in acute myeloid leukaemia (AML). The Bcl‐2‐selective inhibitor ABT‐199 (Venetoclax) shows promising antileukaemic activity against AML, though Mcl‐1 limits its antileukaemic activity. XPO1 is a nuclear exporte...

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Detalles Bibliográficos
Autores principales: Luedtke, Daniel A., Su, Yongwei, Liu, Shuang, Edwards, Holly, Wang, Yue, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237582/
https://www.ncbi.nlm.nih.gov/pubmed/30596398
http://dx.doi.org/10.1111/jcmm.13886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237582/
https://www.ncbi.nlm.nih.gov/pubmed/30596398
http://dx.doi.org/10.1111/jcmm.13886

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