Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation

The mammary luminal lineage relies on the common cytokine-sensing transcription factor STAT5 to establish super-enhancers during pregnancy and initiate a genetic program that activates milk production. As pups grow, the greatly increasing demand for milk requires progressive differentiation of mamma...

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Detalles Bibliográficos
Autores principales: Lee, Hye Kyung, Willi, Michaela, Shin, Ha Youn, Liu, Chengyu, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237736/
https://www.ncbi.nlm.nih.gov/pubmed/30285185
http://dx.doi.org/10.1093/nar/gky891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237736/
https://www.ncbi.nlm.nih.gov/pubmed/30285185
http://dx.doi.org/10.1093/nar/gky891

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