Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?

A(syn)-U/T and G(syn)-C(+) Hoogsteen (HG) base pairs (bps) are energetically more disfavored relative to Watson–Crick (WC) bps in A-RNA as compared to B-DNA by >1 kcal/mol for reasons that are not fully understood. Here, we used NMR spectroscopy, optical melting experiments, molecular dynamics si...

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Detalles Bibliográficos
Autores principales: Rangadurai, Atul, Zhou, Huiqing, Merriman, Dawn K, Meiser, Nathalie, Liu, Bei, Shi, Honglue, Szymanski, Eric S, Al-Hashimi, Hashim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237737/
https://www.ncbi.nlm.nih.gov/pubmed/30285154
http://dx.doi.org/10.1093/nar/gky885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237737/
https://www.ncbi.nlm.nih.gov/pubmed/30285154
http://dx.doi.org/10.1093/nar/gky885

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