SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions

We report a new class of artifacts in DNA methylation measurements from Illumina HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed hybridization to target DNA, often due to germline or somatic deletions and manifest as incorrectly reported intermediate methylation. The a...

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Detalles Bibliográficos
Autores principales: Zhou, Wanding, Triche, Timothy J, Laird, Peter W, Shen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237738/
https://www.ncbi.nlm.nih.gov/pubmed/30085201
http://dx.doi.org/10.1093/nar/gky691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237738/
https://www.ncbi.nlm.nih.gov/pubmed/30085201
http://dx.doi.org/10.1093/nar/gky691

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