Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function

Mtu1(Trmu) is a highly conserved tRNA modifying enzyme responsible for the biosynthesis of τm(5)s(2)U at the wobble position of tRNA(Gln), tRNA(Glu) and tRNA(Lys). Our previous investigations showed that MTU1 mutation modulated the phenotypic manifestation of deafness-associated mitochondrial 12S rR...

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Detalles Bibliográficos
Autores principales: Zhang, Qinghai, Zhang, Luwen, Chen, Danni, He, Xiao, Yao, Shihao, Zhang, Zengming, Chen, Ye, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237746/
https://www.ncbi.nlm.nih.gov/pubmed/30137487
http://dx.doi.org/10.1093/nar/gky758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237746/
https://www.ncbi.nlm.nih.gov/pubmed/30137487
http://dx.doi.org/10.1093/nar/gky758

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