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Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function
Mtu1(Trmu) is a highly conserved tRNA modifying enzyme responsible for the biosynthesis of τm(5)s(2)U at the wobble position of tRNA(Gln), tRNA(Glu) and tRNA(Lys). Our previous investigations showed that MTU1 mutation modulated the phenotypic manifestation of deafness-associated mitochondrial 12S rR...
Autores principales: | Zhang, Qinghai, Zhang, Luwen, Chen, Danni, He, Xiao, Yao, Shihao, Zhang, Zengming, Chen, Ye, Guan, Min-Xin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237746/ https://www.ncbi.nlm.nih.gov/pubmed/30137487 http://dx.doi.org/10.1093/nar/gky758 |
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