A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1

GEN1 is a member of the FEN/EXO family of structure-selective nucleases that cleave 1 nt 3′ to a variety of branchpoints. For each, the H2TH motif binds a monovalent ion and plays an important role in binding one helical arm of the substrates. We investigate here the importance of this metal ion on...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yijin, Freeman, Alasdair DJ, Déclais, Anne-Cécile, Lilley, David M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237754/
https://www.ncbi.nlm.nih.gov/pubmed/30247722
http://dx.doi.org/10.1093/nar/gky863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237754/
https://www.ncbi.nlm.nih.gov/pubmed/30247722
http://dx.doi.org/10.1093/nar/gky863

Ejemplares similares