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A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1
GEN1 is a member of the FEN/EXO family of structure-selective nucleases that cleave 1 nt 3′ to a variety of branchpoints. For each, the H2TH motif binds a monovalent ion and plays an important role in binding one helical arm of the substrates. We investigate here the importance of this metal ion on...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237754/ https://www.ncbi.nlm.nih.gov/pubmed/30247722 http://dx.doi.org/10.1093/nar/gky863 |