Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types

Hyperactivation of Notch signaling and the cellular hypoxic response are frequently observed in cancers, with increasing reports of connections to tumor initiation and progression. The two signaling mechanisms are known to intersect, but while it is well established that hypoxia regulates Notch sign...

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Detalles Bibliográficos
Autores principales: Mutvei, Anders P., Landor, Sebastian K.-J., Fox, Rhys, Braune, Eike-Benjamin, Tsoi, Yat Long, Phoon, Yee Peng, Sahlgren, Cecilia, Hartman, Johan, Bergh, Jonas, Jin, Shaobo, Lendahl, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237764/
https://www.ncbi.nlm.nih.gov/pubmed/29993038
http://dx.doi.org/10.1038/s41388-018-0400-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237764/
https://www.ncbi.nlm.nih.gov/pubmed/29993038
http://dx.doi.org/10.1038/s41388-018-0400-3

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