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Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation
DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins remaining largely unexplored. We used solution NMR spectroscopy, restrained and free molecular dynamics to obtain the structures and investigate dominant...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237784/ https://www.ncbi.nlm.nih.gov/pubmed/30289469 http://dx.doi.org/10.1093/nar/gky893 |