Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation

DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins remaining largely unexplored. We used solution NMR spectroscopy, restrained and free molecular dynamics to obtain the structures and investigate dominant...

Descripción completa

Detalles Bibliográficos
Autores principales: Gruber, David R, Toner, Joanna J, Miears, Heather L, Shernyukov, Andrey V, Kiryutin, Alexey S, Lomzov, Alexander A, Endutkin, Anton V, Grin, Inga R, Petrova, Darya V, Kupryushkin, Maxim S, Yurkovskaya, Alexandra V, Johnson, Eric C, Okon, Mark, Bagryanskaya, Elena G, Zharkov, Dmitry O, Smirnov, Serge L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237784/
https://www.ncbi.nlm.nih.gov/pubmed/30289469
http://dx.doi.org/10.1093/nar/gky893

Ejemplares similares

Ejemplares similares