MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

Nucleotides in the free pool are more susceptible to nonenzymatic methylation than those protected in the DNA double helix. Methylated nucleotides like O6-methyl-dGTP can be mutagenic and toxic if incorporated into DNA. Removal of methylated nucleotides from the nucleotide pool may therefore be impo...

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Detalles Bibliográficos
Autores principales: Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237811/
https://www.ncbi.nlm.nih.gov/pubmed/30304478
http://dx.doi.org/10.1093/nar/gky896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237811/
https://www.ncbi.nlm.nih.gov/pubmed/30304478
http://dx.doi.org/10.1093/nar/gky896

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