Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A(1) Receptor

Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A(1) receptor (A(1)AR), structural binding modes of the receptor PAMs remain unknown. Using the first X-ray structure of the A(1)AR, we have performed all-atom simulations using a robust G...

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Detalles Bibliográficos
Autores principales: Miao, Yinglong, Bhattarai, Apurba, Nguyen, Anh T. N., Christopoulos, Arthur, May, Lauren T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237911/
https://www.ncbi.nlm.nih.gov/pubmed/30442899
http://dx.doi.org/10.1038/s41598-018-35266-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237911/
https://www.ncbi.nlm.nih.gov/pubmed/30442899
http://dx.doi.org/10.1038/s41598-018-35266-x

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