Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study

We characterized the relationship between the plasma concentration of the phospodiesterase (PDE)-4 inhibitor GSK356278 and occupancy of the PDE4 enzyme in the brain of healthy volunteers, using the positron emission tomography (PET) tracer [(11)C](R)-rolipram. To this end, PET scans were acquired in...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Aart, Jasper, Salinas, Cristian, Dimber, Rahul, Pampols-Maso, Sabina, Weekes, Ashley A, Tonkyn, John, Gray, Frank A, Passchier, Jan, Gunn, Roger N, Rabiner, Eugenii A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238179/
https://www.ncbi.nlm.nih.gov/pubmed/28737056
http://dx.doi.org/10.1177/0271678X17720868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238179/
https://www.ncbi.nlm.nih.gov/pubmed/28737056
http://dx.doi.org/10.1177/0271678X17720868

Ejemplares similares