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Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study

We characterized the relationship between the plasma concentration of the phospodiesterase (PDE)-4 inhibitor GSK356278 and occupancy of the PDE4 enzyme in the brain of healthy volunteers, using the positron emission tomography (PET) tracer [(11)C](R)-rolipram. To this end, PET scans were acquired in...

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Detalles Bibliográficos
Autores principales:	van der Aart, Jasper, Salinas, Cristian, Dimber, Rahul, Pampols-Maso, Sabina, Weekes, Ashley A, Tonkyn, John, Gray, Frank A, Passchier, Jan, Gunn, Roger N, Rabiner, Eugenii A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238179/ https://www.ncbi.nlm.nih.gov/pubmed/28737056 http://dx.doi.org/10.1177/0271678X17720868

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