Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction

Hyperammonemia associated with overt hepatic encephalopathy (OHE) causes excitotoxic neuronal death through activation of the cytochrome C (CytC)-mediated mitochondria-dependent apoptotic pathway. We tested the therapeutic effect of nortriptyline (NT), a mitochondrial permeability transition pore (m...

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Detalles Bibliográficos
Autores principales: Jeong, Ji Heun, Kim, Do Kyung, Lee, Nam-Seob, Jeong, Young-Gil, Kim, Ho Won, Kim, Jong-Seok, Han, Seung-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238202/
https://www.ncbi.nlm.nih.gov/pubmed/30428281
http://dx.doi.org/10.1177/1759091418810583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238202/
https://www.ncbi.nlm.nih.gov/pubmed/30428281
http://dx.doi.org/10.1177/1759091418810583

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