Conferring DNA virus resistance with high specificity in plants using virus-inducible genome-editing system

The CRISPR/Cas9 system has recently been engineered to confer resistance to geminiviruses in plants. However, we show here that the usefulness of this antiviral strategy is undermined by off-target effects identified by deep sequencing in Arabidopsis. We construct two virus-inducible CRISPR/Cas9 vec...

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Detalles Bibliográficos
Autores principales: Ji, Xiang, Si, Xiaomin, Zhang, Yi, Zhang, Huawei, Zhang, Feng, Gao, Caixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238286/
https://www.ncbi.nlm.nih.gov/pubmed/30442181
http://dx.doi.org/10.1186/s13059-018-1580-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238286/
https://www.ncbi.nlm.nih.gov/pubmed/30442181
http://dx.doi.org/10.1186/s13059-018-1580-4

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