Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

BACKGROUND: Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (H(2)O(2))-treated neuronal cells. METHODS: SH-SY...

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Detalles Bibliográficos
Autores principales: Liu, Hua, Feng, Yu, Xu, Min, Yang, Jian, Wang, Zhichun, Di, Guangfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238317/
https://www.ncbi.nlm.nih.gov/pubmed/30442144
http://dx.doi.org/10.1186/s12964-018-0294-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238317/
https://www.ncbi.nlm.nih.gov/pubmed/30442144
http://dx.doi.org/10.1186/s12964-018-0294-2

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