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Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

BACKGROUND: Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (H(2)O(2))-treated neuronal cells. METHODS: SH-SY...

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Detalles Bibliográficos
Autores principales:	Liu, Hua, Feng, Yu, Xu, Min, Yang, Jian, Wang, Zhichun, Di, Guangfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238317/ https://www.ncbi.nlm.nih.gov/pubmed/30442144 http://dx.doi.org/10.1186/s12964-018-0294-2

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