BACE2 distribution in major brain cell types and identification of novel substrates

β-Site APP-cleaving enzyme 1 (BACE1) inhibition is considered one of the most promising therapeutic strategies for Alzheimer’s disease, but current BACE1 inhibitors also block BACE2. As the localization and function of BACE2 in the brain remain unknown, it is difficult to predict whether relevant si...

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Detalles Bibliográficos
Autores principales: Voytyuk, Iryna, Mueller, Stephan A, Herber, Julia, Snellinx, An, Moechars, Dieder, van Loo, Geert, Lichtenthaler, Stefan F, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238391/
https://www.ncbi.nlm.nih.gov/pubmed/30456346
http://dx.doi.org/10.26508/lsa.201800026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238391/
https://www.ncbi.nlm.nih.gov/pubmed/30456346
http://dx.doi.org/10.26508/lsa.201800026

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