Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

The contribution of the tumor microenvironment to pancreatic ductal adenocarcinoma (PDAC) development is currently unclear. We therefore examined the consequences of disrupting paracrine Hedgehog (HH) signaling in PDAC stroma. Herein, we show that ablation of the key HH signaling gene Smoothened (Sm...

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Detalles Bibliográficos
Autores principales: Pitarresi, Jason R, Liu, Xin, Avendano, Alex, Thies, Katie A, Sizemore, Gina M, Hammer, Anisha M, Hildreth, Blake E, Wang, David J, Steck, Sarah A, Donohue, Sydney, Cuitiño, Maria C, Kladney, Raleigh D, Mace, Thomas A, Chang, Jonathan J, Ennis, Christina S, Li, Huiqing, Reeves, Roger H, Blackshaw, Seth, Zhang, Jianying, Yu, Lianbo, Fernandez, Soledad A, Frankel, Wendy L, Bloomston, Mark, Rosol, Thomas J, Lesinski, Gregory B, Konieczny, Stephen F, Guttridge, Denis C, Rustgi, Anil K, Leone, Gustavo, Song, Jonathan W, Wu, Jinghai, Ostrowski, Michael C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238420/
https://www.ncbi.nlm.nih.gov/pubmed/30456390
http://dx.doi.org/10.26508/lsa.201800190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238420/
https://www.ncbi.nlm.nih.gov/pubmed/30456390
http://dx.doi.org/10.26508/lsa.201800190

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