Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the D...

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Detalles Bibliográficos
Autores principales: Kumbhar, Ramhari, Vidal-Eychenié, Sophie, Kontopoulos, Dimitrios-Georgios, Larroque, Marion, Larroque, Christian, Basbous, Jihane, Kossida, Sofia, Ribeyre, Cyril, Constantinou, Angelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238597/
https://www.ncbi.nlm.nih.gov/pubmed/30456359
http://dx.doi.org/10.26508/lsa.201800096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238597/
https://www.ncbi.nlm.nih.gov/pubmed/30456359
http://dx.doi.org/10.26508/lsa.201800096

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