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Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

The Fanconi anemia pathway for DNA interstrand crosslink repair and the translesion synthesis pathway for DNA damage tolerance both require cycles of monoubiquitination and deubiquitination. The ubiquitin-specific protease-1 (USP1), in complex with USP1-associated factor 1, regulates multiple DNA re...

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Detalles Bibliográficos
Autores principales: Arkinson, Connor, Chaugule, Viduth K, Toth, Rachel, Walden, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238601/
https://www.ncbi.nlm.nih.gov/pubmed/30456385
http://dx.doi.org/10.26508/lsa.201800162