Barcoding chemical modifications into nucleic acids improves drug stability in vivo

The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As...

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Detalles Bibliográficos
Autores principales: Sago, Cory D., Kalathoor, Sujay, Fitzgerald, Jordan P., Lando, Gwyneth N., Djeddar, Naima, Bryksin, Anton V., Dahlman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238725/
https://www.ncbi.nlm.nih.gov/pubmed/30555697
http://dx.doi.org/10.1039/c8tb01642a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238725/
https://www.ncbi.nlm.nih.gov/pubmed/30555697
http://dx.doi.org/10.1039/c8tb01642a

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