Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

PURPOSE: We evaluated prevention of transforming growth factor β (TGFβ)–induced transdifferentiation of cultured scleral fibroblasts to myofibroblasts by rho-associated protein kinase (ROCK) inhibitors. Additionally, we tested whether local delivery of ROCK inhibitors reduced scleral fibroblast prol...

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Detalles Bibliográficos
Autores principales: Pitha, Ian, Oglesby, Ericka, Chow, Amanda, Kimball, Elizabeth, Pease, Mary Ellen, Schaub, Julie, Quigley, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238981/
https://www.ncbi.nlm.nih.gov/pubmed/30479877
http://dx.doi.org/10.1167/tvst.7.6.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238981/
https://www.ncbi.nlm.nih.gov/pubmed/30479877
http://dx.doi.org/10.1167/tvst.7.6.6

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