Reprogramming human T cell function and specificity with non-viral genome targeting

Decades of work have aimed to genetically reprogram T cells for therapeutic purposes(1) using recombinant viral vectors, which do not target transgenes to specific genomic sites(2,3). In addition, the need for viral vectors has slowed down research and clinical use as their manufacturing and testing...

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Detalles Bibliográficos
Autores principales: Roth, Theodore L., Puig-Saus, Cristina, Yu, Ruby, Shifrut, Eric, Carnevale, Julia, Li, P. Jonathan, Hiatt, Joseph, Saco, Justin, Krystofinski, Paige, Li, Han, Tobin, Victoria, Nguyen, David N., Lee, Michael R., Putnam, Amy L., Ferris, Andrea L., Chen, Jeff W., Schickel, Jean-Nicolas, Pellerin, Laurence, Carmody, David, Alkorta-Aranburu, Gorka, Gaudio, Daniela Del, Matsumoto, Hiroyuki, Morell, Montse, Mao, Ying, Cho, Min, Quadros, Rolen M., Gurumurthy, Channabasavaiah B., Smith, Baz, Haugwitz, Michael, Hughes, Stephen H., Weissman, Jonathan S., Schumann, Kathrin, Esensten, Jonathan H., May, Andrew P., Ashworth, Alan, Kupfer, Gary M., Greeley, Siri Atma W., Bacchetta, Rosa, Meffre, Eric, Roncarolo, Maria Grazia, Romberg, Neil, Herold, Kevan C., Ribas, Antoni, Leonetti, Manuel D., Marson, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239417/
https://www.ncbi.nlm.nih.gov/pubmed/29995861
http://dx.doi.org/10.1038/s41586-018-0326-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239417/
https://www.ncbi.nlm.nih.gov/pubmed/29995861
http://dx.doi.org/10.1038/s41586-018-0326-5

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