Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression

Loss of silencing of the DUX4 gene on chromosome 4 causes facioscapulohumeral muscular dystrophy. While high level DUX4 expression induces apoptosis, the effects of low level DUX4 expression on human myogenic cells are not well understood. Low levels and sporadic expression of DUX4 have been reporte...

Descripción completa

Detalles Bibliográficos
Autores principales: Bosnakovski, Darko, Gearhart, Micah D., Toso, Erik A., Ener, Elizabeth T., Choi, Si Ho, Kyba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240038/
https://www.ncbi.nlm.nih.gov/pubmed/30446688
http://dx.doi.org/10.1038/s41598-018-35150-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240038/
https://www.ncbi.nlm.nih.gov/pubmed/30446688
http://dx.doi.org/10.1038/s41598-018-35150-8

Ejemplares similares