Cargando…

The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

Whole-genome sequencing was used to analyze the profiles of isoniazid (INH) resistance-related mutations among 188 multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and mono-INH-resistant isolates collected in a recent Chinese national survey. Mutations were detected in 18 structura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Liguo, Jiang, Fengting, Chen, Lihong, Zhao, Bing, Dong, Jie, Sun, Lilian, Zhu, Yafang, Liu, Bo, Zhou, Yang, Yang, Jian, Zhao, Yanlin, Jin, Qi, Zhang, Xiaobing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240042/ https://www.ncbi.nlm.nih.gov/pubmed/30446638 http://dx.doi.org/10.1038/s41426-018-0184-0

Ejemplares similares

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic
por: Isakova, Jainagul, et al.
Publicado: (2018)

Pattern of InhA and KatG mutations in isoniazid monoresistant Mycobacterium tuberculosis isolates
por: Charan, Ashok Singh, et al.
Publicado: (2020)

Detection of KatG/inhA Mutation to Guide Isoniazid and Ethionamide Use for Drug-resistant Tuberculosis
por: Namburete, Evangelina
Publicado: (2017)

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC
por: Nieto R, Luisa Maria, et al.
Publicado: (2016)

Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America
por: Dalla Costa, Elis R, et al.
Publicado: (2009)

Molecular Characterization of katG and inhA Mutations by Genotype MTBDRplus Line Probe Assay To Guide Isoniazid and Ethionamide Use for Drug-Resistant Tuberculosis
por: Ranjan, K. P., et al.
Publicado: (2023)

Investigation of Ser315 Substitutions within katG Gene in Isoniazid-Resistant Clinical Isolates of Mycobacterium tuberculosis from South India
por: Unissa, A. Nusrath, et al.
Publicado: (2015)

In house reverse membrane hybridisation assay versus GenoType MTBDRplus and their performance to detect mutations in the genes rpoB, katG and inhA
por: Ferreira, Sergio Luiz Montego, et al.
Publicado: (2014)

Isoniazid resistance and the point mutation of codon 463 of katG gene of Mycobacterium tuberculosis.
por: Shim, T. S., et al.
Publicado: (1997)

Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser(315)
por: Jeeves, Rose E., et al.
Publicado: (2015)

Frequency of rpoB, katG, and inhA Gene Polymorphisms Associated with Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates among Ethiopian TB Patients: A Systematic Review
por: Seid, Aynias, et al.
Publicado: (2022)

Distinct H(2)O(2)-Scavenging System in Yersinia pseudotuberculosis: KatG and AhpC Act Together to Scavenge Endogenous Hydrogen Peroxide
por: Wan, Fen, et al.
Publicado: (2021)

Two Novel katG Mutations Conferring Isoniazid Resistance in Mycobacterium tuberculosis
por: Hsu, Li-Yu, et al.
Publicado: (2020)

Clarity with INHindsight: High-Dose Isoniazid for Drug-Resistant Tuberculosis with inhA Mutations
por: Wasserman, Sean, et al.
Publicado: (2020)

Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates
por: Torres, Jessica N, et al.
Publicado: (2015)

Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA
por: Kumar, Vivek, et al.
Publicado: (2015)

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis
por: Harrison, Gregory A., et al.
Publicado: (2023)

Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates
por: Abkar, Roya, et al.
Publicado: (2016)

Isoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran
por: Moaddab, Seed Reza, et al.
Publicado: (2011)

Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis
por: Zhang, Bing, et al.
Publicado: (2019)

Molecular Analysis of katG Encoding Catalase-Peroxidase from Clinical Isolate of Isoniazid-Resistant Mycobacterium tuberculosis
por: Purkan, P, et al.
Publicado: (2018)

Drug resistance and the genotypic characteristics of rpoB and katG in rifampicin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates in central Vietnam
por: Nguyen, Thi Binh Nguyen, et al.
Publicado: (2023)

Regulation of the ahpC Gene Encoding Alkyl Hydroperoxide Reductase in Mycobacterium smegmatis
por: Lee, Ha-Na, et al.
Publicado: (2014)

Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam
por: Hang, Nguyen Thi Le, et al.
Publicado: (2019)

Predictive Power of ETRE Polymorphism and Katg463 Mutation to INH-Resistance of M.tuberculosis
por: WEN, Yu-feng, et al.
Publicado: (2015)

Binding Thermodynamics and Dissociation Kinetics Analysis Uncover the Key Structural Motifs of Phenoxyphenol Derivatives as the Direct InhA Inhibitors and the Hotspot Residues of InhA
por: Zhang, Qianqian, et al.
Publicado: (2022)

Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors
por: Sabbah, Mohamad, et al.
Publicado: (2020)

The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology
por: Song, Yanhua, et al.
Publicado: (2021)

Construction and use of a prokaryotic expression system for Helicobacter pylori AhpC
por: Mehmood, Khalid, et al.
Publicado: (2012)

Role of Alkyl Hydroperoxide Reductase (AhpC) in the Biofilm Formation of Campylobacter jejuni
por: Oh, Euna, et al.
Publicado: (2014)

Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods
por: Takawira, Faustinos Tatenda, et al.
Publicado: (2017)

Intracellular targeting of ascomycetous catalase-peroxidases (KatG1s)
por: Zámocký, Marcel, et al.
Publicado: (2013)

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
por: Xia, Yi, et al.
Publicado: (2018)

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors
por: Sabbah, Mohamad, et al.
Publicado: (2020)

Deciphering Isoniazid Drug Resistance Mechanisms on Dimeric Mycobacterium tuberculosis KatG via Post-molecular Dynamics Analyses Including Combined Dynamic Residue Network Metrics
por: Barozi, Victor, et al.
Publicado: (2022)

Role of peroxiredoxin of the AhpC/TSA family in antioxidant defense mechanisms of Francisella tularensis
por: Alharbi, Arwa, et al.
Publicado: (2019)

Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC
por: Schmidt, Lindsey K., et al.
Publicado: (2022)

Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis
por: Munir, Asma, et al.
Publicado: (2021)

Low-Shear Modeled Microgravity Enhances Salmonella Enterica Resistance to Hydrogen Peroxide Through a Mechanism Involving KatG and KatN
por: Pacello, Francesca, et al.
Publicado: (2012)

KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin
por: Loewen, Peter C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fgo07g4j8bh62i6tngifg5one3