Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase

Fructokinase (FRK) catalyzes the first step of fructose metabolism i.e., D-fructose to D-fructose-6-phosphate (F6P), however, the mechanistic insights of this reaction are elusive yet. Here we demonstrate that the putative Vibrio cholerae fructokinase (VcFRK) exhibit strong fructose-6-kinase activit...

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Detalles Bibliográficos
Autores principales: Paul, Rakhi, Chatterjee, Shramana, Nath, Seema, Sen, Udayaditya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240065/
https://www.ncbi.nlm.nih.gov/pubmed/30446722
http://dx.doi.org/10.1038/s41598-018-35236-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240065/
https://www.ncbi.nlm.nih.gov/pubmed/30446722
http://dx.doi.org/10.1038/s41598-018-35236-3

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