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Mechanistic Interaction Study of Bromo-Noscapine with Bovine Serum Albumin employing Spectroscopic and Chemoinformatics Approaches

Bromo-Noscapine (BrNs) is a tubulin-binding cytotoxic agent with significant activity against breast and lung cancer. The mechanistic interaction insight into the binding of bovine serum albumin (BSA) with BrNs can provide critical information about the pharmacodynamics and pharmacokinetics properti...

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Detalles Bibliográficos
Autores principales: Sood, Damini, Kumar, Neeraj, Rathee, Garima, Singh, Anju, Tomar, Vartika, Chandra, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240080/
https://www.ncbi.nlm.nih.gov/pubmed/30446713
http://dx.doi.org/10.1038/s41598-018-35384-6