Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms

BACKGROUND: Interactions between the protein synthesis inhibitor homoharringtonine (HHT) and the proteasome inhibitor bortezomib were investigated in DLBCL and mantle cell lymphoma cells (MCL). METHODS: Various DLBCL and MCL cells were exposed to HHT and bortezomib alone or together after which apop...

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Detalles Bibliográficos
Autores principales: Nguyen, Tri, Parker, Rebecca, Zhang, Yu, Hawkins, Elisa, Kmieciak, Maciej, Craun, William, Grant, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240231/
https://www.ncbi.nlm.nih.gov/pubmed/30445933
http://dx.doi.org/10.1186/s12885-018-5018-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240231/
https://www.ncbi.nlm.nih.gov/pubmed/30445933
http://dx.doi.org/10.1186/s12885-018-5018-x

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