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Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms

BACKGROUND: Interactions between the protein synthesis inhibitor homoharringtonine (HHT) and the proteasome inhibitor bortezomib were investigated in DLBCL and mantle cell lymphoma cells (MCL). METHODS: Various DLBCL and MCL cells were exposed to HHT and bortezomib alone or together after which apop...

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Detalles Bibliográficos
Autores principales:	Nguyen, Tri, Parker, Rebecca, Zhang, Yu, Hawkins, Elisa, Kmieciak, Maciej, Craun, William, Grant, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240231/ https://www.ncbi.nlm.nih.gov/pubmed/30445933 http://dx.doi.org/10.1186/s12885-018-5018-x

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