A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

BACKGROUND: Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined mechanisms of a SGLT2-inhibitor...

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Detalles Bibliográficos
Autores principales: Durak, Aysegul, Olgar, Yusuf, Degirmenci, Sinan, Akkus, Erman, Tuncay, Erkan, Turan, Belma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240275/
https://www.ncbi.nlm.nih.gov/pubmed/30447687
http://dx.doi.org/10.1186/s12933-018-0790-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240275/
https://www.ncbi.nlm.nih.gov/pubmed/30447687
http://dx.doi.org/10.1186/s12933-018-0790-0

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