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How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

OBJECTIVE: Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU). The aim of this analysis was to determine how many milligrams of allopurinol above the recommended CrCL-based dose (R+) are required to achieve tar...

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Detalles Bibliográficos
Autores principales: Stamp, Lisa K., Chapman, Peter T., Barclay, Murray L., Horne, Anne, Frampton, Christopher, Tan, Paul, Drake, Jill, Dalbeth, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240322/
https://www.ncbi.nlm.nih.gov/pubmed/30446002
http://dx.doi.org/10.1186/s13075-018-1755-0