Autocrine-Paracrine Prostaglandin E(2) Signaling Restricts TLR4 internalization and TRIF Signaling

The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal transduction cascades: a Mal (TIRAP)–MyD88-dependent signal from the cell surface that regulates proinflammatory cytokines and a TRAM–TRIF-dependent signal from endosomes that drives type I interferon production....

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Detalles Bibliográficos
Autores principales: Perkins, Darren J., Richard, Katharina, Hansen, Anne-Marie, Lai, Wendy, Nallar, Shreeram, Koller, Beverly, Vogel, Stefanie N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240378/
https://www.ncbi.nlm.nih.gov/pubmed/30397349
http://dx.doi.org/10.1038/s41590-018-0243-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240378/
https://www.ncbi.nlm.nih.gov/pubmed/30397349
http://dx.doi.org/10.1038/s41590-018-0243-7

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