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Autocrine-Paracrine Prostaglandin E(2) Signaling Restricts TLR4 internalization and TRIF Signaling
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal transduction cascades: a Mal (TIRAP)–MyD88-dependent signal from the cell surface that regulates proinflammatory cytokines and a TRAM–TRIF-dependent signal from endosomes that drives type I interferon production....
Autores principales: | Perkins, Darren J., Richard, Katharina, Hansen, Anne-Marie, Lai, Wendy, Nallar, Shreeram, Koller, Beverly, Vogel, Stefanie N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240378/ https://www.ncbi.nlm.nih.gov/pubmed/30397349 http://dx.doi.org/10.1038/s41590-018-0243-7 |
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