Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamate (PAG) – a compound with neuroprotective properti...

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Detalles Bibliográficos
Autores principales: Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Vyklicky, Vojtech, Ladislav, Marek, Hubalkova, Pavla, Krausova, Barbora, Smejkalova, Tereza, Nekardova, Michaela, Smidkova, Marketa, Monincova, Lenka, Soucek, Radko, Vyklicky, Ladislav, Kudova, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240685/
https://www.ncbi.nlm.nih.gov/pubmed/30483134
http://dx.doi.org/10.3389/fphar.2018.01299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240685/
https://www.ncbi.nlm.nih.gov/pubmed/30483134
http://dx.doi.org/10.3389/fphar.2018.01299

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