Cargando…

Patient-Derived Induced Pluripotent Stem Cells and Organoids for Modeling Alpha Synuclein Propagation in Parkinson's Disease

Parkinson's disease (PD) is an age-associated, progressive neurodegenerative disorder characterized by motor impairment and in some cases cognitive decline. Central to the disease pathogenesis of PD is a small, presynaptic neuronal protein known as alpha synuclein (a-syn), which tends to accumu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koh, Yong Hui, Tan, Li Yi, Ng, Shi-Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240766/ https://www.ncbi.nlm.nih.gov/pubmed/30483063 http://dx.doi.org/10.3389/fncel.2018.00413

Ejemplares similares

Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
por: Lai, Thuy Thi, et al.
Publicado: (2021)

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
por: Zhang, Guoxin, et al.
Publicado: (2018)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
por: Fitzgerald, Emily, et al.
Publicado: (2019)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
por: Fields, Carroll Rutherford, et al.
Publicado: (2019)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Brainstem Organoids From Human Pluripotent Stem Cells
por: Eura, Nobuyuki, et al.
Publicado: (2020)

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
por: Ferreira, Sara A., et al.
Publicado: (2018)

Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
por: Chan, Daniel Kam Yin, et al.
Publicado: (2017)

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease
por: Tönges, Lars, et al.
Publicado: (2014)

Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough
por: Ganguly, Upasana, et al.
Publicado: (2021)

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease
por: Canerina-Amaro, Ana, et al.
Publicado: (2019)

Alterations of Erythrocytic Phosphorylated Alpha-Synuclein in Different Subtypes and Stages of Parkinson's Disease
por: Li, Xu-Ying, et al.
Publicado: (2021)

Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
por: Su, Ruichen, et al.
Publicado: (2021)

Patient-specific pluripotent stem cell-based Parkinson’s disease models showing endogenous alpha-synuclein aggregation
por: Oh, Yohan
Publicado: (2019)

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
por: Bernis, Maria E., et al.
Publicado: (2015)

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease
por: Jewett, Michael, et al.
Publicado: (2018)

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
por: Booms, Alix, et al.
Publicado: (2021)

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson’s Disease
por: Hernandez, Sarah M., et al.
Publicado: (2020)

Parkinson’s Disease Dementia: Synergistic Effects of Alpha-Synuclein, Tau, Beta-Amyloid, and Iron
por: Han, Jiajun, et al.
Publicado: (2021)

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
por: Hou, Kaiying, et al.
Publicado: (2023)

Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model
por: Huang, Jing, et al.
Publicado: (2017)

Pathological alpha-synuclein propagates through neural networks
por: Masuda-Suzukake, Masami, et al.
Publicado: (2014)

Gene Editing in Pluripotent Stem Cells and Their Derived Organoids
por: Zhou, Hang, et al.
Publicado: (2021)

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease
por: Gilmozzi, Valentina, et al.
Publicado: (2020)

Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease
por: Guo, Mengyuan, et al.
Publicado: (2022)

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
por: Brembati, Viviana, et al.
Publicado: (2023)

Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
por: Fukusumi, Hayato, et al.
Publicado: (2021)

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein
por: Shimozawa, Aki, et al.
Publicado: (2019)

Applications of kidney organoids derived from human pluripotent stem cells
por: Kim, Yong Kyun, et al.
Publicado: (2018)

Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease
por: Piper, Desiree A., et al.
Publicado: (2018)

Genetic Elements at the Alpha-Synuclein Locus
por: Prahl, Jordan, et al.
Publicado: (2022)

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression
por: Fagen, Sara J., et al.
Publicado: (2023)

Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids
por: Chang, Mingyang, et al.
Publicado: (2021)

Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease
por: Sepúlveda, Denisse, et al.
Publicado: (2022)

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
por: Devine, Michael J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jr6s0vl3447n3v9mni86hudknk