Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization

Degradable polymer prodrugs based on gemcitabine (Gem) as an anticancer drug were synthesized by ‘drug-initiated’ nitroxide-mediated radical ring-opening copolymerization (NMrROP) of methacrylic esters and 2-methylene-4-phenyl-1,3-dioxolane (MPDL). Different structural parameters were varied to dete...

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Detalles Bibliográficos
Autores principales: Guégain, Elise, Tran, Johanna, Deguettes, Quentin, Nicolas, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240899/
https://www.ncbi.nlm.nih.gov/pubmed/30542578
http://dx.doi.org/10.1039/c8sc02256a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240899/
https://www.ncbi.nlm.nih.gov/pubmed/30542578
http://dx.doi.org/10.1039/c8sc02256a

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