Cargando…

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

OBJECTIVE: DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), while TP53/PIK3CA/PTEN alterations are as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singhi, Aatur D, McGrath, Kevin, Brand, Randall E, Khalid, Asif, Zeh, Herbert J, Chennat, Jennifer S, Fasanella, Kenneth E, Papachristou, Georgios I, Slivka, Adam, Bartlett, David L, Dasyam, Anil K, Hogg, Melissa, Lee, Kenneth K, Marsh, James Wallis, Monaco, Sara E, Ohori, N Paul, Pingpank, James F, Tsung, Allan, Zureikat, Amer H, Wald, Abigail I, Nikiforova, Marina N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Pancreas
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241612/ https://www.ncbi.nlm.nih.gov/pubmed/28970292 http://dx.doi.org/10.1136/gutjnl-2016-313586

Ejemplares similares

Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures
por: Singhi, Aatur D, et al.
Publicado: (2020)

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size
por: Hackeng, Wenzel M, et al.
Publicado: (2022)

The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program
por: Levink, Iris J. M., et al.
Publicado: (2023)

Monitoring Ca19‐9 during pancreatic cyst surveillance: Better safe than sorry?
por: Perri, Giampaolo, et al.
Publicado: (2023)

Impact of genomic profiling on the treatment and outcomes of patients with advanced gastrointestinal malignancies
por: Dhir, Mashaal, et al.
Publicado: (2016)

A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising From Pancreatic Cysts
por: Nikiforova, Marina N., et al.
Publicado: (2023)

Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age
por: Chao, David T., et al.
Publicado: (2018)

Endoscopic Ultrasound–Guided Creation of a Gastrogastric Conduit After Pancreaticoduodenectomy in a Patient with Prior Roux-en-Y Gastric Bypass
por: Das, Rohit, et al.
Publicado: (2018)

Clinical usefulness of scoring systems to predict severe acute pancreatitis: A systematic review and meta‐analysis with pre and post‐test probability assessment
por: Capurso, Gabriele, et al.
Publicado: (2023)

Quantitative MRI of chronic pancreatitis: results from a multi-institutional prospective study, magnetic resonance imaging as a non-invasive method for assessment of pancreatic fibrosis (MINIMAP)
por: Tirkes, Temel, et al.
Publicado: (2022)

Incidence and risk factors of oral feeding intolerance in acute pancreatitis: Results from an international, multicenter, prospective cohort study
por: Pothoulakis, Ioannis, et al.
Publicado: (2021)

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
por: Hessmann, E, et al.
Publicado: (2018)

Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected
por: Machicado, Jorge D., et al.
Publicado: (2021)

Branch-duct intraductal papillary mucinous neoplasm (IPMN): Are cyst volumetry and other novel imaging features able to improve malignancy prediction compared to well-established resection criteria?
por: Pozzi Mucelli, Raffaella M., et al.
Publicado: (2022)

Obesity and alcoholic etiology as risk factors for multisystem organ failure in acute pancreatitis: Multinational study
por: Lee, Peter J., et al.
Publicado: (2023)

Impact of Tumor Grade on Prognosis in Pancreatic Cancer: Should We Include Grade in AJCC Staging?
por: Wasif, Nabil, et al.
Publicado: (2010)

KRAS Amplification in Metastatic Colon Cancer is Associated with a History of Inflammatory Bowel Disease and May Confer Resistance to anti-EGFR Therapy
por: Favazza, Laura A., et al.
Publicado: (2020)

Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables
por: Scholten, Lianne, et al.
Publicado: (2020)

SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma
por: Fei, Naomi, et al.
Publicado: (2021)

MRI follow-up for pancreatic intraductal papillary mucinous neoplasm: an ultrashort versus long protocol
por: Johansson, Katarina, et al.
Publicado: (2021)

Ferumoxytol-enhanced MR imaging for differentiating intrapancreatic splenules from other tumors
por: Muehler, M. R., et al.
Publicado: (2020)

Prediction of infected pancreatic necrosis in acute necrotizing pancreatitis by the modified pancreatitis activity scoring system
por: Mao, Wenjian, et al.
Publicado: (2022)

Development of a volumetric pancreas segmentation CT dataset for AI applications through trained technologists: a study during the COVID 19 containment phase
por: Suman, Garima, et al.
Publicado: (2020)

Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
por: Nywening, Timothy M, et al.
Publicado: (2018)

Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma
por: Raj, Deepak, et al.
Publicado: (2019)

The impact of race/ethnicity on pancreaticoduodenectomy outcomes for pancreatic cancer
por: Alwatari, Yahya, et al.
Publicado: (2022)

Prevalence, features, and explanations of missed and misinterpreted pancreatic cancer on imaging: a matched case–control study
por: Hoogenboom, Sanne A., et al.
Publicado: (2022)

Autoimmune pancreatitis results from loss of TGFβ signalling in S100A4-positive dendritic cells
por: Boomershine, C S, et al.
Publicado: (2009)

MRI with hyperpolarised [1-(13)C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model
por: Serrao, Eva M, et al.
Publicado: (2016)

Adaptive Dynamic Therapy and Survivorship for Operable Pancreatic Cancer
por: AlMasri, Samer, et al.
Publicado: (2022)

Long-term yield of pancreatic cancer surveillance in high-risk individuals
por: Overbeek, Kasper A, et al.
Publicado: (2022)

Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
por: Bellomo, Gaia, et al.
Publicado: (2022)

Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours
por: Huang, Hsi-Chien, et al.
Publicado: (2022)

Targeting mTOR dependency in pancreatic cancer
por: Morran, Douglas C, et al.
Publicado: (2014)

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine
por: Murthy, Pranav, et al.
Publicado: (2019)

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
por: Rosendahl, Jonas, et al.
Publicado: (2018)

CT-monitored minimal ablative margin control in single-session microwave ablation of liver tumors: an effective strategy for local tumor control
por: Joo, Ijin, et al.
Publicado: (2022)

Combination 5-fluorouracil, folinic acid and cisplatin (LV5FU2-CDDP) followed by gemcitabine or the reverse sequence in metastatic pancreatic cancer: final results of a randomised strategic phase III trial (FFCD 0301)
por: Dahan, Laetitia, et al.
Publicado: (2010)

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca(2+)-dependent mitochondrial dysfunction and acute pancreatitis
por: Huang, Wei, et al.
Publicado: (2014)

Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis
por: Hart, Phil A, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_manmssoak8mo5ianndj5v5uibe